The endothelial glycocalyx is a thin gel-like layer that coats the entire luminal side of the vascular endothelium1. Its functions in vascular and micro-vascular health include:
The primary active ingredient of ArterosilHP is rhamnan sulfate, derived from Monostroma nitidum, a rare green seaweed found in east Asia.
Rhamnan sulfate, a negatively charged polysaccharide, was reported to posses anticoagulant and antithrombotic activity by some early studies13,14 and this was verified by other researchers later15.
Rhamnan sulfate has a similar chemical structure to heparan sulfate found abundantly in human endothelial glycocalyx and may exert its biological activities by regenerating endothelial glycocalyx.Read More See References
To evaluate ArterosilHP for supporting healthy endothelial function, a randomized double blinded clinical study was conducted at Medicus Research in California.
The results clearly demonstrated that ArterosilHP supplementation ameliorated the damage of endothelial glycocalyx and the loss of endothelial function caused by a high fat high sugar meal in the healthy human subjects.Read About the Human Clinical Trial
Tests using lab animals showed rhamnan sulfate reversed the leukocytes adherence to endothelium induced by enzymatic removal of glycocalyx (unpublished data).
Other researchers have reported that rhamnan sulfate enhances the endothelial glycocalyx and decreases the LDL permeability of human coronary artery endothelial cells16.
A Japanese study demonstrated that daily supplementation of a crude rhamnan sulfate extract for 6 weeks significantly lowered total and LDL cholesterol in borderline or mild hypercholesterolemia human subjects17
Another study also from Japan later showed that oral administration of crude extract of rhamnan sulfate to carbohydrate-loaded rats significantly reduced their blood glucose level compared to the control animals18.See References